< Latin sequēla : see sequel n.
1.a. Pathol. A morbid affection occurring as the result of a previous disease. Chiefly pl.
b. transf. A consequence. (OED)
"Because mammalian PFKs are known to contain an allosteric activation site (which binds ADP/AMP) and a catalytic site (which binds ATP), we considered the possibility that acyl-CoAs could bind to an adenine-based regulatory site and modulate PFK-1 activity to integrate glycolytic flux with fatty acid oxidation. Such a mechanism would be of particular relevance considering the well established accumulation of activated fatty acid derivatives (e.g. fatty acyl-CoA and acyl-carnitine) and their deleterious sequelae in lipid-related disease states such as diabetes, hepatic steatosis, hyperlipidemia, and related component parts of the metabolic syndrome."
- Christopher M. Jenkins et al., "Reversible High Affinity Inhibition of Phosphofructokinase-1 by Acyl-CoA", JBC 286:11937 (8 April 2011)
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