Friday, October 30, 2015

Word and molecule of the day: amitriptyline

The word and molecule of the day is amitriptyline:

Tricyclic antidepressant with anticholinergic and sedative properties. Amitriptyline hydrochloride appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines. (

"See those hummingbirds?

"I painted those with a silver-tipped paintbrush and an unopened bottle of mint-cream amitriptyline"

 - Michael Dickman, "Green migraine", 26 October 2015 The New Yorker (

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