Thursday, March 01, 2012

Molecule of the day: tyloxapol

The molecule of the day is tyloxapol:

The seminar I went to presented it as a standard lysosome toxin, but a quick search on the interwebs mostly emphasizes its role as a non-ionic detergent, and even searching for "tyloxapol lysosomes" only mentions its use to purify lysosomes (lysosomes readily take up tyloxapol, which makes them more buoyant, which makes them easier to separate from other cellular components by centrifugation (source)).

So perhaps the speaker mispoke, and meant that it was a lipase toxin.  Tyloxapol is apparently also known as Triton WR 1339, which is reported to inhibit lipoprotein lipase (source).

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