Showing posts with label inhibitors. Show all posts
Showing posts with label inhibitors. Show all posts

Friday, September 07, 2012

Monday, August 13, 2012

molecule of the day: deoxypyridoxine

The molecule of the day is deoxypyridoxine:


It's a vitamin B6 antagonist, so my guess is that it inhibits sphingosine-1-phosphate lyase, because it uses pyridoxal

 
 as a cofactor, and I think that's why this paper includes it in their sphingosine kinase assay mix.  I think.

Saturday, August 04, 2012

molecule of the day: quercetin

The molecule of the day is quercetin:

(PubChem)

It's an antioxidant.  It also apparently inhibits at least some diacylglycerol kinases.  The authors don't really discuss why they thought quercetin might inhibit their enzyme, but it's in the same section as the nucleotide analogs: maybe the flat fused rings targets the nucleotide binding site?

Thursday, July 26, 2012

Wednesday, July 25, 2012

molecule of the day: diisopropyl fluorophosphate

The molecule of the day is diisopropyl fluorophosphate:

(PubChem)

 Like other organophosphates (the most famous being sarin), it inhibits cholinesterases, but also lipases.  (And if the authors appreciated how dangerous this chemical they were working with was, they don't mention it in the methods.)


Tuesday, July 24, 2012

molecule of the day: leupeptin

The molecule of the day is leupeptin:

(PubChem)
It's a protease inhibitor produced by actinomycetes (source), which, as far as I can tell, is a polyphyletic group.